THE SMALLEST COMPLETE HIV-1 TREATMENT

Pill size does not reflect how safe a treatment is or how well a treatment works.

Pill shown is not actual size. Actual size is 15.4 mm x 7.3 mm.

ODEFSEY® is a complete HIV-1 treatment that combines 3 different medicines into 1 small pill*, taken once a day with a meal. ODEFSEY should not be taken with other HIV-1 medicines.

ODEFSEY is used to treat HIV-1 in people 12 years and older. It can be used in people who are either:

Starting HIV-1 treatment, have never taken medicines before, and have less than 100,000 copies/mL of virus in their blood, OR

Replacing their current HIV-1 medicines and whose healthcare provider determines they meet certain requirements. These include having an undetectable viral load (less than 50 copies/mL) for 6 months or more on their current HIV-1 treatment.

ODEFSEY does not cure HIV-1 or AIDS. You must keep taking HIV-1 medicines to control HIV-1 infection and decrease HIV-related illnesses.

It's important to know what's inside your treatment and how it works. A complete treatment contains at least three different medicines, all of which are important and work together.

ODEFSEY® combines the following medicines into a single pill:


Please see Important Facts about
ODEFSEY and DESCOVY,

including important warnings.

Whether you are new to treatment or replacing your current HIV-1 medicine, ask your healthcare provider if ODEFSEY is right for you.

Whether you are new to treatment or replacing your current HIV-1 medicine, ask your healthcare provider if ODEFSEY is right for you.

Important Safety Information

What is the most important information I should know about ODEFSEY®?

ODEFSEY may cause serious side effects:

Who should not take ODEFSEY?

Do not take ODEFSEY if you take:

What are the other possible side effects of ODEFSEY?

Serious side effects of ODEFSEY may also include:

The most common side effects of rilpivirine, one of the medicines in ODEFSEY, are depression, trouble sleeping (insomnia), and headache.

The most common side effect of emtricitabine and tenofovir alafenamide, two of the medicines in ODEFSEY, is nausea.

Tell your healthcare provider if you have any side effects that bother you or do not go away.

What should I tell my healthcare provider before taking ODEFSEY?

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call .

What is ODEFSEY?

ODEFSEY is a 1-pill, once-a-day prescription medicine used to treat HIV-1 in people 12 years and older. It can either be used in people who are starting HIV-1 treatment, have never taken HIV-1 medicines before, and have an amount of HIV-1 in their blood ("viral load") that is no more than 100,000 copies/mL; or in people who are replacing their current HIV-1 medicines and whose healthcare provider determines they meet certain requirements. These include having an undetectable viral load (less than 50 copies/mL) for 6 months or more on their current HIV-1 treatment. ODEFSEY combines 3 medicines into 1 pill taken once a day with a meal. ODEFSEY is a complete HIV-1 treatment and should not be used with other HIV-1 medicines.

ODEFSEY does not cure HIV-1 infection or AIDS. To control HIV-1 infection and decrease HIV-related illnesses, you must keep taking ODEFSEY. Ask your healthcare provider if you have questions about how to reduce the risk of passing HIV-1 to others. Always practice safer sex and use condoms to lower the chance of sexual contact with body fluids. Never reuse or share needles or other items that have body fluids on them.

Please see Important Facts about ODEFSEY, including important warnings.